Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts.
Science
; 341(6153): 1514-7, 2013 Sep 27.
Article
en En
| MEDLINE
| ID: mdl-24030491
The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Salmonella
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Salmonelosis Animal
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Salmonella typhimurium
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Zoonosis
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Farmacorresistencia Bacteriana Múltiple
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Interacciones Huésped-Patógeno
Límite:
Animals
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Humans
Idioma:
En
Revista:
Science
Año:
2013
Tipo del documento:
Article