Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery.
Chem Soc Rev
; 43(1): 444-72, 2014 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-24100581
ABSTRACT
The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sistemas de Liberación de Medicamentos
/
Nanocompuestos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Soc Rev
Año:
2014
Tipo del documento:
Article
País de afiliación:
Bélgica