Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum.
Clin Exp Immunol
; 175(2): 150-66, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24128276
ABSTRACT
Vascular inflammation contributes to the defence against invading microbes and to the repair of injured tissues. In most cases it resolves before becoming apparent. Vasculitis comprises heterogeneous clinical entities that are characterized by the persistence of vascular inflammation after it has served its homeostatic function. Most underlying mechanisms have so far remained elusive. Intravascular immunity refers to the surveillance of the vasculature by leucocytes that sense microbial or sterile threats to vessel integrity and initiate protective responses that entail most events that determine the clinical manifestations of vasculitis, such as end-organ ischaemia, neutrophil extracellular traps generation and thrombosis, leucocyte extravasation and degranulation. Understanding how the resolution of vascular inflammation goes awry in patients with systemic vasculitis will facilitate the identification of novel pharmacological targets and bring us a step closer in each patient to the selection of more effective and less toxic treatments.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vasos Sanguíneos
/
Vasculitis Sistémica
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Immunol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia