Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.
Mol Carcinog
; 54(7): 523-31, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-24293253
ABSTRACT
Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vejiga Urinaria
/
Neoplasias de la Vejiga Urinaria
/
Regulación Neoplásica de la Expresión Génica
/
Histona Desacetilasas
Límite:
Adult
/
Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Mol Carcinog
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Portugal