Predicted multiple selected reaction monitoring to screen activated drug-mediated modifications on human serum albumin.

Osaki, Fumio; Goto, Takaaki; Lee, Seon Hwa; Oe, Tomoyuki

Osaki, Fumio; Goto, Takaaki; Lee, Seon Hwa; Oe, Tomoyuki.

Afiliación

Osaki F; Department of Bio-analytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan; Analysis and Pharmacokinetics Research Labs, Astellas Pharma, Inc., Ibaraki 305-8585, Japan.
Goto T; Department of Bio-analytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.
Lee SH; Department of Bio-analytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.
Oe T; Department of Bio-analytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan. Electronic address: t-oe@mail.pharm.tohoku.ac.jp.

Anal Biochem ; 449: 59-67, 2014 Mar 15.

Article en En | MEDLINE | ID: mdl-24361714

Asunto(s)

Benzoquinonas/metabolismo; Iminas/metabolismo; Cetoprofeno/análogos & derivados; Albúmina Sérica/química; Albúmina Sérica/metabolismo; Secuencia de Aminoácidos; Sitios de Unión; Cisteína/análisis; Cisteína/metabolismo; Humanos; Cetoprofeno/metabolismo; Lisina/análisis; Lisina/metabolismo; Espectrometría de Masas/métodos; Datos de Secuencia Molecular; Preparaciones Farmacéuticas/metabolismo; Unión Proteica

Palabras clave

Activated drug; Chemical modification; Human serum albumin; Mass spectrometry; Predicted multiple selected reaction monitoring; Screening

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Albúmina Sérica / Cetoprofeno / Benzoquinonas / Iminas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Anal Biochem Año: 2014 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google