Correlation of pain with objective quantification of magnetic resonance images in older adults with chronic low back pain.
Spine (Phila Pa 1976)
; 39(6): 469-75, 2014 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-24384652
ABSTRACT
STUDY DESIGN:
Cross sectional study.OBJECTIVE:
The goal of this study is to identify relationships between objectively measured and subjectively scored parameters and reported pain. SUMMARY OF BACKGROUND DATA Studies have demonstrated the unreliability of magnetic resonance imaging (MRI)-based parameters to identify pathological pain generators of chronic low back pain, but they were based on visual inspection and subjective assessment of lumbar disc features. Advancements in computer image analysis provide objective measurements of lumbar disc features.METHODS:
Two radiologists evaluated 39 axial and sagittal T1- and T2-weighted MR images of patients with chronic axial low back pain (age, >65 yr) and graded 4 subjective lumbar disc parameters (T2 signal intensity, nucleus shape, Modic changes, and osteophyte formation) whose sum is the cumulative MRI score. Objective parameter, MRI index, was calculated as the product of the measured lumbar disc area and total disc MRI signal intensity. Discs were sorted from least to the most degenerated relative to each parameter. Pearson correlation coefficient and multiple linear regression analysis were performed between the reported pain score and each parameter.RESULTS:
The most and least degenerated discs in each patient, as assessed by MRI index, had the highest negative and positive correlation coefficient and regression weight contribution, respectively. All subjective parameters had low correlation coefficients and regression goodness of fit.CONCLUSION:
Although limited by small sample size, the objective parameter, MRI index, can be a potential imaging biomarker used to identify possible pain generators. This study presents a potential new application of MR imaging in identifying pain generators of patients with chronic low back pain.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dimensión del Dolor
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Imagen por Resonancia Magnética
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Dolor de la Región Lumbar
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Degeneración del Disco Intervertebral
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Percepción del Dolor
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Dolor Crónico
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Disco Intervertebral
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Vértebras Lumbares
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Spine (Phila Pa 1976)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Panamá