Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

García, Samuel; Krausz, Sarah; Ambarus, Carmen A; Fernández, Beatriz Malvar; Hartkamp, Linda M; van Es, Inge E; Hamann, Jörg; Baeten, Dominique L; Tak, Paul P; Reedquist, Kris A

García, Samuel; Krausz, Sarah; Ambarus, Carmen A; Fernández, Beatriz Malvar; Hartkamp, Linda M; van Es, Inge E; Hamann, Jörg; Baeten, Dominique L; Tak, Paul P; Reedquist, Kris A.

Afiliación

García S; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Krausz S; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Ambarus CA; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Fernández BM; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Hartkamp LM; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
van Es IE; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Hamann J; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands.
Baeten DL; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Tak PP; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.
Reedquist KA; Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.

PLoS One ; 9(1): e82088, 2014.

Article en En | MEDLINE | ID: mdl-24404127

Asunto(s)

Activación de Macrófagos/inmunología; Macrófagos/inmunología; Macrófagos/metabolismo; Fenotipo; Receptor TIE-2/metabolismo; Transducción de Señal; Factores de Necrosis Tumoral/metabolismo; Angiopoyetina 1/farmacología; Angiopoyetina 2/farmacología; Citocinas/biosíntesis; Citocinas/genética; Expresión Génica; Perfilación de la Expresión Génica; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Inflamación/inmunología; Inflamación/metabolismo; Quinasas Janus/metabolismo; Activación de Macrófagos/efectos de los fármacos; Macrófagos/efectos de los fármacos; Monocitos/efectos de los fármacos; Monocitos/inmunología; Monocitos/metabolismo; Receptor TIE-2/genética; Factores de Transcripción STAT/metabolismo; Factor de Necrosis Tumoral alfa/farmacología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenotipo / Transducción de Señal / Receptor TIE-2 / Factores de Necrosis Tumoral / Activación de Macrófagos / Macrófagos Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Países Bajos

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