Lanthanide-doped LiLuF(4) upconversion nanoprobes for the detection of disease biomarkers.
Angew Chem Int Ed Engl
; 53(5): 1252-7, 2014 Jan 27.
Article
en En
| MEDLINE
| ID: mdl-24436151
ABSTRACT
Lanthanide-doped upconversion nanoparticles (UCNPs) have shown great promise in bioapplications. Exploring new host materials to realize efficient upconversion luminescence (UCL) output is a goal of general concern. Herein, we develop a unique strategy for the synthesis of novel LiLuF4Ln(3+) core/shell UCNPs with typically high absolute upconversion quantum yields of 5.0 % and 7.6 % for Er(3+) and Tm(3+) , respectively. Based on our customized UCL biodetection system, we demonstrate for the first time the application of LiLuF4Ln(3+) core/shell UCNPs as sensitive UCL bioprobes for the detection of an important disease marker ßâ
subunit of human chorionic gonadotropin (ß-hCG) with a detection limit of 3.8â
ng mL(-1) , which is comparable to the ß-hCG level in the serum of normal humans. Furthermore, we use these UCNPs in proof-of-concept computed tomography imaging and UCL imaging of cancer cells, thus revealing the great potential of LiLuF4Ln(3+) UCNPs as efficient nano-bioprobes in disease diagnosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
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Elementos de la Serie de los Lantanoides
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Nanopartículas del Metal
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Gonadotropina Coriónica
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Litio
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Lutecio
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2014
Tipo del documento:
Article