The intracellular carboxyl terminal domain of Vangl proteins contains plasma membrane targeting signals.
Protein Sci
; 23(4): 337-43, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24452931
ABSTRACT
Vangl1 and Vangl2 are integral membrane proteins that play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. Their proper targeting to the plasma membrane (PM) is required for function. We created discrete deletions at the amino and carboxy termini of Vangl1 and monitored the effect of the mutations on PM targeting in Madin-Darby canine kidney cells. Our results show that the Vangl1 amino terminus lacks PM targeting determinants, and these are restricted to the carboxy terminus, including the predicted PDZBM motif at the C-terminus.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Señales de Clasificación de Proteína
/
Proteínas Portadoras
/
Membrana Celular
/
Proteínas de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Protein Sci
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Canadá