Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?
Breast Cancer Res
; 16(1): 202, 2014 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-24476463
ABSTRACT
Paracrine signaling mechanisms play a critical role in both normal mammary gland development and breast cancer. Dissection of these mechanisms using genetically engineered mouse models has provided significant insight into our understanding of the mechanisms that guide intratumoral heterogeneity. In the following perspective, we briefly review some of the emerging concepts in this field and emphasize why elucidation of these pathways will be important for future progress in devising new and improved combinatorial therapeutic approaches for breast and other solid cancers.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Mamarias Animales
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Comunicación Paracrina
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Glándulas Mamarias Animales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2014
Tipo del documento:
Article