Triclocarban-induced change in intracellular Ca²âº level in rat thymocytes: cytometric analysis with Fluo-3 under Zn²âº-free conditions.
Environ Toxicol Pharmacol
; 37(2): 563-70, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24562054
ABSTRACT
Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca(2+) concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca(2+). TCC at concentrations ranging from 0.1 µM to 3 µM increased intracellular Ca(2+) concentration biphasically first by releasing Ca(2+) from intracellular Ca(2+) stores and then inducing Ca(2+) influx through store-operated Ca(2+) channels. The threshold TCC concentration to increase intracellular Ca(2+) concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca(2+) signaling in human lymphocytes.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Contaminantes Químicos del Agua
/
Carbanilidas
/
Calcio
/
Timocitos
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Antiinfecciosos Locales
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón