Mode of action of diterpene and characterization of related metabolites from the soft coral, Xenia elongata.
Mar Drugs
; 12(2): 1102-15, 2014 Feb 20.
Article
en En
| MEDLINE
| ID: mdl-24562393
ABSTRACT
Chemical and biological investigation of the cultured marine soft coral Xenia elongata led to the isolation of two new diterpenes (2, 3). Their structures were elucidated using a combination of NMR and mass spectrometry. Biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line D3 deficient in Bak and Bax and derived from a mouse epithelial cell. The diterpenes induce apoptosis in low micromolar concentrations. The results indicate that the previously isolated compound (1) affects cell in a manner similar to that of HSP90 and HDAC inhibitors and in a manner opposite of PI3 kinase/mTOR inhibitors. Compound (3) inhibits selectively HDAC6 in high micromolar concentrations.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apoptosis
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Antozoos
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Diterpenos
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Células Epiteliales
Límite:
Animals
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos