Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.

Komatsu, Hidetoshi; Maruyama, Minoru; Yao, Shuuhei; Shinohara, Tokuyuki; Sakuma, Kensuke; Imaichi, Sachiko; Chikatsu, Tomoko; Kuniyeda, Kanako; Siu, Foo Kok; Peng, Lam Sock; Zhuo, Katherine; Mun, Lay Sock; Han, Tan Min; Matsumoto, Yoshio; Hashimoto, Tadatoshi; Miyajima, Nobuyuki; Itoh, Yasuaki; Ogi, Kazuhiro; Habata, Yugo; Mori, Masaaki

Komatsu, Hidetoshi; Maruyama, Minoru; Yao, Shuuhei; Shinohara, Tokuyuki; Sakuma, Kensuke; Imaichi, Sachiko; Chikatsu, Tomoko; Kuniyeda, Kanako; Siu, Foo Kok; Peng, Lam Sock; Zhuo, Katherine; Mun, Lay Sock; Han, Tan Min; Matsumoto, Yoshio; Hashimoto, Tadatoshi; Miyajima, Nobuyuki; Itoh, Yasuaki; Ogi, Kazuhiro; Habata, Yugo; Mori, Masaaki.

Afiliación

Komatsu H; Central Nervous System Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Maruyama M; Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Yao S; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Shinohara T; Advanced Science Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Sakuma K; Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Imaichi S; Advanced Science Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Chikatsu T; Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Kuniyeda K; Extra Value Generation and General Medicine Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Siu FK; TSP CNS Phenotyping, Takeda Pharmaceutical Company Limited, Singapore.
Peng LS; TSP CNS Phenotyping, Takeda Pharmaceutical Company Limited, Singapore.
Zhuo K; TSP Transgenic pipeline, Takeda Pharmaceutical Company Limited, Singapore.
Mun LS; TSP Transgenic pipeline, Takeda Pharmaceutical Company Limited, Singapore.
Han TM; TSP Transgenic pipeline, Takeda Pharmaceutical Company Limited, Singapore.
Matsumoto Y; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Hashimoto T; Research Administration Department, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Miyajima N; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Itoh Y; Pharmaceutical Marketing Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Ogi K; Advanced Science Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Habata Y; Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Mori M; Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.

PLoS One ; 9(2): e90134, 2014.

Article en En | MEDLINE | ID: mdl-24587241

Asunto(s)

Trastornos Psicóticos/genética; Receptores Acoplados a Proteínas G/genética; Transcriptoma; Secuencia de Aminoácidos; Animales; Antipsicóticos/farmacología; Conducta Animal/efectos de los fármacos; Cognición/efectos de los fármacos; Secuencia Conservada; Cuerpo Estriado/efectos de los fármacos; Cuerpo Estriado/metabolismo; Cuerpo Estriado/fisiopatología; Neuronas Dopaminérgicas/efectos de los fármacos; Neuronas Dopaminérgicas/metabolismo; Neuronas Dopaminérgicas/patología; Emociones/efectos de los fármacos; Perfilación de la Expresión Génica; Regulación de la Expresión Génica; Humanos; Ratones; Ratones Transgénicos; Datos de Secuencia Molecular; Trastornos Psicóticos/tratamiento farmacológico; Trastornos Psicóticos/metabolismo; Trastornos Psicóticos/fisiopatología; Receptores de Dopamina D1/genética; Receptores de Dopamina D1/metabolismo; Receptores de Dopamina D2/genética; Receptores de Dopamina D2/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Reserpina/farmacología; Transducción de Señal; Área Tegmental Ventral/efectos de los fármacos; Área Tegmental Ventral/metabolismo; Área Tegmental Ventral/fisiopatología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Receptores Acoplados a Proteínas G / Transcriptoma Tipo de estudio: Diagnostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Japón

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