M3 muscarinic receptor interaction with phospholipase C ß3 determines its signaling efficiency.

Kan, Wei; Adjobo-Hermans, Merel; Burroughs, Michael; Faibis, Guy; Malik, Sundeep; Tall, Gregory G; Smrcka, Alan V

Kan, Wei; Adjobo-Hermans, Merel; Burroughs, Michael; Faibis, Guy; Malik, Sundeep; Tall, Gregory G; Smrcka, Alan V.

Afiliación

Kan W; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Adjobo-Hermans M; Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.
Burroughs M; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Faibis G; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Malik S; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Tall GG; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Smrcka AV; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Biochemistry and Biophysics and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Aab Institute of Cardiovascular Research, Universit

J Biol Chem ; 289(16): 11206-11218, 2014 Apr 18.

Article en En | MEDLINE | ID: mdl-24596086

Asunto(s)

Membrana Celular/metabolismo; Subunidades alfa de la Proteína de Unión al GTP Gq-G11/metabolismo; Fosfolipasa C beta/metabolismo; Receptor Muscarínico M3/metabolismo; Transducción de Señal/fisiología; Animales; Células CHO; Membrana Celular/genética; Cricetinae; Cricetulus; Subunidades alfa de la Proteína de Unión al GTP Gq-G11/genética; Humanos; Fosfolipasa C beta/genética; Unión Proteica; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Receptor Muscarínico M3/genética

Palabras clave

G Protein-coupled Receptors (GPCR); G Proteins; Phosphatidylinositol Signaling; Phospholipase C; Protein-Protein Interactions; Scaffolding

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Membrana Celular / Subunidades alfa de la Proteína de Unión al GTP Gq-G11 / Receptor Muscarínico M3 / Fosfolipasa C beta Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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