Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers.
Nat Methods
; 11(5): 545-8, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24633409
ABSTRACT
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sustancias Macromoleculares
/
Rayos Láser
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nat Methods
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos