Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

Esteban, Gerard; Allan, Jennifer; Samadi, Abdelouahid; Mattevi, Andrea; Unzeta, Mercedes; Marco-Contelles, José; Binda, Claudia; Ramsay, Rona R

Esteban, Gerard; Allan, Jennifer; Samadi, Abdelouahid; Mattevi, Andrea; Unzeta, Mercedes; Marco-Contelles, José; Binda, Claudia; Ramsay, Rona R.

Afiliación

Esteban G; Departamento de Bioquímica i Biología Molecular, Institute of Neuroscience, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Allan J; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 8QP, UK.
Samadi A; Laboratorio de Química Medica (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
Mattevi A; Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy.
Unzeta M; Departamento de Bioquímica i Biología Molecular, Institute of Neuroscience, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Marco-Contelles J; Laboratorio de Química Medica (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
Binda C; Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy. Electronic address: claudia.binda@unipv.it.
Ramsay RR; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 8QP, UK. Electronic address: rrr@st-and.ac.uk.

Biochim Biophys Acta ; 1844(6): 1104-10, 2014 Jun.

Article en En | MEDLINE | ID: mdl-24642166

Asunto(s)

Indoles/química; Inhibidores de la Monoaminooxidasa/química; Monoaminooxidasa/química; Fármacos Neuroprotectores/química; Piperidinas/química; Acetilcolinesterasa/química; Butirilcolinesterasa/química; Clorgilina/química; Donepezilo; Flavina-Adenina Dinucleótido/química; Humanos; Indanos/química; Cinética; Modelos Moleculares; Monoaminooxidasa/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/metabolismo

Palabras clave

ASS234; Alzheimer's disease; Crystal structure; Flavin adduct; Multi-target drug; PF9601N

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Fármacos Neuroprotectores / Indoles / Monoaminooxidasa / Inhibidores de la Monoaminooxidasa Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2014 Tipo del documento: Article País de afiliación: España

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