Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.

Song, Daisheng; Li, Lin-sheng; Arsenault, Patrick R; Tan, Qiulin; Bigham, Abigail W; Heaton-Johnson, Katherine J; Master, Stephen R; Lee, Frank S

Song, Daisheng; Li, Lin-sheng; Arsenault, Patrick R; Tan, Qiulin; Bigham, Abigail W; Heaton-Johnson, Katherine J; Master, Stephen R; Lee, Frank S.

Afiliación

Song D; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Li LS; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Arsenault PR; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Tan Q; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Bigham AW; the Department of Anthropology, University of Michigan, Ann Arbor, Michigan 48109.
Heaton-Johnson KJ; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Master SR; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Lee FS; From the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and franklee@mail.med.upenn.edu.

J Biol Chem ; 289(21): 14656-65, 2014 May 23.

Article en En | MEDLINE | ID: mdl-24711448

Asunto(s)

Altitud; Prolina Dioxigenasas del Factor Inducible por Hipoxia/metabolismo; Oxidorreductasas Intramoleculares/metabolismo; Oxígeno/metabolismo; Adaptación Fisiológica; Secuencias de Aminoácidos/genética; Secuencia de Aminoácidos; Animales; Western Blotting; Hipoxia de la Célula; Células Cultivadas; Embrión de Mamíferos/citología; Fibroblastos/citología; Fibroblastos/metabolismo; Células HEK293; Proteínas HSP90 de Choque Térmico/genética; Proteínas HSP90 de Choque Térmico/metabolismo; Haplotipos; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Prolina Dioxigenasas del Factor Inducible por Hipoxia/genética; Oxidorreductasas Intramoleculares/genética; Ratones; Ratones Noqueados; Polimorfismo de Nucleótido Simple; Prostaglandina-E Sintasas; Unión Proteica; Tibet

Palabras clave

EGLN1; Evolution; Hypoxia; Hypoxia-inducible Factor; Hypoxia-inducible Factor (HIF); Mutant; PHD2

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Oxidorreductasas Intramoleculares / Altitud / Prolina Dioxigenasas del Factor Inducible por Hipoxia Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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