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IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.
Grassian, Alexandra R; Parker, Seth J; Davidson, Shawn M; Divakaruni, Ajit S; Green, Courtney R; Zhang, Xiamei; Slocum, Kelly L; Pu, Minying; Lin, Fallon; Vickers, Chad; Joud-Caldwell, Carol; Chung, Franklin; Yin, Hong; Handly, Erika D; Straub, Christopher; Growney, Joseph D; Vander Heiden, Matthew G; Murphy, Anne N; Pagliarini, Raymond; Metallo, Christian M.
Afiliación
  • Grassian AR; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Parker SJ; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Davidson SM; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Divakaruni AS; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Green CR; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Zhang X; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Slocum KL; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Pu M; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Lin F; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Vickers C; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Joud-Caldwell C; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Chung F; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Yin H; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Handly ED; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Straub C; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Growney JD; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Vander Heiden MG; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Murphy AN; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Pagliarini R; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
  • Metallo CM; Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California
Cancer Res ; 74(12): 3317-31, 2014 Jun 15.
Article en En | MEDLINE | ID: mdl-24755473
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciclo del Ácido Cítrico / Mutación Missense / Isocitrato Deshidrogenasa / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciclo del Ácido Cítrico / Mutación Missense / Isocitrato Deshidrogenasa / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article