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Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Volgraf, Matthew; Chan, Lina; Huestis, Malcolm P; Purkey, Hans E; Burkard, Michael; Geck Do, Mary; Harris, Julie; Hunt, Kevin W; Liu, Xingrong; Lyssikatos, Joseph P; Rana, Sumeet; Thomas, Allen A; Vigers, Guy P A; Siu, Michael.
Afiliación
  • Volgraf M; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: volgrafm@gene.com.
  • Chan L; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Huestis MP; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Purkey HE; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Burkard M; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Geck Do M; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Harris J; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Hunt KW; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Liu X; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Lyssikatos JP; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Rana S; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Thomas AA; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Vigers GP; Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, United States.
  • Siu M; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Bioorg Med Chem Lett ; 24(11): 2477-80, 2014 Jun 01.
Article en En | MEDLINE | ID: mdl-24780121
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazoles / Inhibidores de Proteasas / Benzopiranos / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazoles / Inhibidores de Proteasas / Benzopiranos / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article