Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells.
Stem Cells
; 32(9): 2397-406, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24802280
ABSTRACT
Cardiosphere-derived cells (CDCs) effect therapeutic regeneration after myocardial infarction (MI) both in animal models and in humans. Here, we test the hypothesis that cell-cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects. Human CDCs or vehicle were injected into immunodeficient (SCID) mouse hearts during acute MI. CDC transplantation augmented the proportion of cycling (Ki67(+) ) cardiomyocytes and improved ventricular function. CDC-conditioned media only modestly augmented the percentage of Ki67(+) cardiomyocytes (>control but Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Comunicación Celular
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Miocitos Cardíacos
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Miocardio
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Stem Cells
Año:
2014
Tipo del documento:
Article