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An antidepressant decreases CSF Aß production in healthy individuals and in transgenic AD mice.
Sheline, Yvette I; West, Tim; Yarasheski, Kevin; Swarm, Robert; Jasielec, Mateusz S; Fisher, Jonathan R; Ficker, Whitney D; Yan, Ping; Xiong, Chengjie; Frederiksen, Christine; Grzelak, Monica V; Chott, Robert; Bateman, Randall J; Morris, John C; Mintun, Mark A; Lee, Jin-Moo; Cirrito, John R.
Afiliación
  • Sheline YI; Departments of Psychiatry, Radiology, and Neurology, University of Pennsylvania, Philadelphia , PA 19104, USA. sheline@mail.med.upenn.edu.
  • West T; C2N Diagnostics LLC, St. Louis, MO 63110, USA.
  • Yarasheski K; Department of Medicine, Washington University, St. Louis, MO 63110, USA.
  • Swarm R; Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.
  • Jasielec MS; Department of Biostatistics, Washington University, St. Louis, MO 63110, USA.
  • Fisher JR; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
  • Ficker WD; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
  • Yan P; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
  • Xiong C; Department of Biostatistics, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
  • Frederiksen C; Department of Surgery, Washington University, St. Louis, MO 63110, USA.
  • Grzelak MV; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
  • Chott R; Department of Medicine, Washington University, St. Louis, MO 63110, USA.
  • Bateman RJ; Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
  • Morris JC; Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
  • Mintun MA; Avid Radiopharmaceuticals and Eli Lilly Inc., Philadelphia, PA 19104, USA.
  • Lee JM; Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
  • Cirrito JR; Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
Sci Transl Med ; 6(236): 236re4, 2014 May 14.
Article en En | MEDLINE | ID: mdl-24828079
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citalopram / Precursor de Proteína beta-Amiloide / Enfermedad de Alzheimer / Antidepresivos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citalopram / Precursor de Proteína beta-Amiloide / Enfermedad de Alzheimer / Antidepresivos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos