F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).

Liu, Jia; Han, Liang; Li, Bin; Yang, Jie; Huen, Michael S Y; Pan, Xin; Tsao, Sai Wah; Cheung, Annie L M

Liu, Jia; Han, Liang; Li, Bin; Yang, Jie; Huen, Michael S Y; Pan, Xin; Tsao, Sai Wah; Cheung, Annie L M.

Afiliación

Liu J; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Han L; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Li B; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Yang J; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Huen MS; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Pan X; the Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892.
Tsao SW; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and.
Cheung AL; From the Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China and lmcheung@hku.hk.

J Biol Chem ; 289(31): 21508-18, 2014 Aug 01.

Article en En | MEDLINE | ID: mdl-24936062

Asunto(s)

Proteínas F-Box/fisiología; Lisina/metabolismo; MAP Quinasa Quinasa 6/metabolismo; Transducción de Señal/fisiología; Proteínas Supresoras de Tumor/fisiología; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo; Apoptosis; Secuencia de Bases; Línea Celular Tumoral; Proteínas F-Box/genética; Células HEK293; Humanos; Mutagénesis Sitio-Dirigida; Oligodesoxirribonucleótidos; Estrés Oxidativo; Proteolisis; Proteínas Supresoras de Tumor/genética; Ubiquitinación

Palabras clave

Apoptosis; Cancer; F-box Protein; FBXO31; MKK6; Protein Degradation; Stress Response; Ubiquitination; p38 MAPK

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Supresoras de Tumor / Proteínas F-Box / MAP Quinasa Quinasa 6 / Proteínas Quinasas p38 Activadas por Mitógenos / Lisina Límite: Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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