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Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Koehler, Michael F T; Bergeron, Philippe; Choo, Edna F; Lau, Kevin; Ndubaku, Chudi; Dudley, Danette; Gibbons, Paul; Sleebs, Brad E; Rye, Carl S; Nikolakopoulos, George; Bui, Chinh; Kulasegaram, Sanji; Kersten, Wilhelmus J A; Smith, Brian J; Czabotar, Peter E; Colman, Peter M; Huang, David C S; Baell, Jonathan B; Watson, Keith G; Hasvold, Lisa; Tao, Zhi-Fu; Wang, Le; Souers, Andrew J; Elmore, Steven W; Flygare, John A; Fairbrother, Wayne J; Lessene, Guillaume.
Afiliación
  • Koehler MF; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Bergeron P; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Choo EF; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Lau K; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Ndubaku C; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Dudley D; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Gibbons P; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Sleebs BE; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Rye CS; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Nikolakopoulos G; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Bui C; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Kulasegaram S; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Kersten WJ; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Smith BJ; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Czabotar PE; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Colman PM; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Huang DC; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Baell JB; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Watson KG; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
  • Hasvold L; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Tao ZF; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Wang L; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Souers AJ; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Elmore SW; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Flygare JA; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Fairbrother WJ; Departments of Discovery Chemistry, Drug Metabolism and Pharmacokinetics, and Early Discovery Biochemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Lessene G; Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, Victoria, Australia.
ACS Med Chem Lett ; 5(6): 662-7, 2014 Jun 12.
Article en En | MEDLINE | ID: mdl-24944740
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos