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Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.
Bras, Jose; Guerreiro, Rita; Darwent, Lee; Parkkinen, Laura; Ansorge, Olaf; Escott-Price, Valentina; Hernandez, Dena G; Nalls, Michael A; Clark, Lorraine N; Honig, Lawrence S; Marder, Karen; Van Der Flier, Wiesje M; Lemstra, Afina; Scheltens, Philip; Rogaeva, Ekaterina; St George-Hyslop, Peter; Londos, Elisabet; Zetterberg, Henrik; Ortega-Cubero, Sara; Pastor, Pau; Ferman, Tanis J; Graff-Radford, Neill R; Ross, Owen A; Barber, Imelda; Braae, Anne; Brown, Kristelle; Morgan, Kevin; Maetzler, Walter; Berg, Daniela; Troakes, Claire; Al-Sarraj, Safa; Lashley, Tammaryn; Compta, Yaroslau; Revesz, Tamas; Lees, Andrew; Cairns, Nigel; Halliday, Glenda M; Mann, David; Pickering-Brown, Stuart; Dickson, Dennis W; Singleton, Andrew; Hardy, John.
Afiliación
  • Bras J; Department of Molecular Neuroscience, j.bras@ucl.ac.uk.
  • Guerreiro R; Department of Molecular Neuroscience.
  • Darwent L; Department of Molecular Neuroscience.
  • Parkkinen L; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.
  • Ansorge O; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.
  • Escott-Price V; MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.
  • Hernandez DG; Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, USA.
  • Nalls MA; Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, USA.
  • Clark LN; Taub Institute for Alzheimer Disease and the Aging Brain, Department of Pathology and Cell Biology, and.
  • Honig LS; Taub Institute for Alzheimer Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
  • Marder K; Taub Institute for Alzheimer Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
  • Van Der Flier WM; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
  • Lemstra A; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
  • Scheltens P; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
  • Rogaeva E; Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • St George-Hyslop P; Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge CB2
  • Londos E; Clinical Memory Research Unit, Institute Clinical Sciences Malmö, Lund University, Sweden.
  • Zetterberg H; Department of Molecular Neuroscience, Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Ortega-Cubero S; Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain, Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain, CIBERNED, Centro de Investigación Biomédica en Red de
  • Pastor P; Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain, Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain, CIBERNED, Centro de Investigación Biomédica en Red de
  • Ferman TJ; Department of Psychiatry, Department of Psychology.
  • Graff-Radford NR; Department of Neurology and.
  • Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Barber I; Translation Cell Sciences - Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
  • Braae A; Translation Cell Sciences - Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
  • Brown K; Translation Cell Sciences - Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
  • Morgan K; Translation Cell Sciences - Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
  • Maetzler W; Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany.
  • Berg D; Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany.
  • Troakes C; MRC London Neurodegenerative Diseases Brain Bank, Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, UK.
  • Al-Sarraj S; MRC London Neurodegenerative Diseases Brain Bank, Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, UK.
  • Lashley T; Queen Square Brain Bank, Department of Molecular Neuroscience, and.
  • Compta Y; Queen Square Brain Bank, Department of Molecular Neuroscience, and Parkinson's disease and Movement Disorders Unit, Neurology Service, IDIBAPS, CIBERNED, Hospital Clínic, Barcelona, Catalonia, Spain.
  • Revesz T; Queen Square Brain Bank, Department of Molecular Neuroscience, and.
  • Lees A; Queen Square Brain Bank, Department of Molecular Neuroscience, and.
  • Cairns N; Knight Alzheimer's Disease Research Center and Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.
  • Halliday GM; Neuroscience Research Australia, Sydney, Australia, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.
  • Mann D; Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK and.
  • Pickering-Brown S; Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK and.
  • Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Singleton A; Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, USA.
  • Hardy J; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Hum Mol Genet ; 23(23): 6139-46, 2014 Dec 01.
Article en En | MEDLINE | ID: mdl-24973356
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Enfermedad por Cuerpos de Lewy / Proteínas de Membrana de los Lisosomas / Receptores Depuradores / Alfa-Sinucleína / Lisosomas Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Enfermedad por Cuerpos de Lewy / Proteínas de Membrana de los Lisosomas / Receptores Depuradores / Alfa-Sinucleína / Lisosomas Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article