CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK.
Arch Biochem Biophys
; 558: 120-6, 2014 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-24977325
ABSTRACT
We report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. We also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and stemness through Notch1 signaling in breast cancer cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
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Estabilidad del ARN
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Proteínas Quinasas p38 Activadas por Mitógenos
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Antígeno CD24
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Receptor Notch1
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Transición Epitelial-Mesenquimal
Límite:
Humans
Idioma:
En
Revista:
Arch Biochem Biophys
Año:
2014
Tipo del documento:
Article