13C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response.
Analyst
; 139(20): 5134-9, 2014 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-25134792
ABSTRACT
(13)C-engineered carbon quantum dots ((13)C-QDs) were used as magnetic resonance (MR) and fluorescence dual-response probe. The enhanced (13)C-MR signal was observed at 171 ppm from carboxylic and carboxyl carbons in (13)C-QDs with 160-fold improvement on signal-to-noise ratio even when no hyperpolarization was applied, whereas the intrinsic fluorescence of C-QDs was still maintained. The stable MR and fluorescence dual-response was successfully used for long-term observation of zebrafish embryonic development. Cross-validation between MR and fluorescence confirmed the distribution of (13)C-QD in zebrafish. (13)C-MR provides specific information about the presence, magnitude, and progression of (13)C-QDs by defining MR intensity, whereas fluorescence reveals the location of (13)C-QDs with its high sensitivity. (13)C-MR and fluorescence was simultaneously observed within (13)C-QDs, and this work may expand the applications of isotope-engineered nanomaterials.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Espectroscopía de Resonancia Magnética
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Puntos Cuánticos
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Microscopía Fluorescente
Límite:
Animals
Idioma:
En
Revista:
Analyst
Año:
2014
Tipo del documento:
Article
País de afiliación:
China