Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele.
Alzheimers Dement
; 11(6): 648-57.e1, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25160043
ABSTRACT
BACKGROUND:
Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk.METHODS:
We evaluated APOE-related differences in BOLD activation in response to a memory task, cerebrovascular reactivity using a CO2-inhalation challenge (CO2-CVR), and the potential contribution of CO2-CVR to the BOLD signal.RESULTS:
APOE ε4-carriers had the highest task-related hippocampal BOLD signal relative to non-carriers. The largest differences in CO2-CVR were between ε2- and ε4-carriers, with the latter having the lowest values. Genotype differences in CO2-CVR accounted for â¼70% of hippocampal BOLD differences between groups.CONCLUSION:
Because CO2-CVR gauges vascular health, the differential effect of APOE in young adults may reflect a vascular contribution to the vulnerability of ε4-carriers to late-life pathology. Studies confirming our findings are warranted.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Circulación Cerebrovascular
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Apolipoproteína E4
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Heterocigoto
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Dement
Año:
2015
Tipo del documento:
Article