Epilepsy and antiepileptic drugs: risk factors for atherosclerosis.
Int J Neurosci
; 125(7): 507-11, 2015.
Article
en En
| MEDLINE
| ID: mdl-25164095
ABSTRACT
INTRODUCTION:
Epilepsy is a chronic disease that affects metabolism either alone or through the antiepileptic drug (AED) treatment. A risk of atherosclerosis has been found in epileptic patients.AIM:
Prove the potential role of epilepsy and/or its treatment as atherosclerotic risk factors. SUBJECT ANDMETHODS:
Forty Egyptian patients with primary idiopathic epilepsy were compared to 20 healthy controls. B-mode ultrasound examination of the common carotid artery intima-media thickness (CCA IMT), measurement of serum lipid profile, fibrinogen and high sensitive C-reactive protein were performed to both groups.RESULTS:
Patients had significantly increased right and left CCA IMT (p < 0.05); elevated levels of HDL (p < 0.01) and hs-CRP (p = 0.009) in comparison to control subjects. Positive correlation was found between IMT and hs-CRP (p < 0.05) as well as fibrinogen level (p < 0.05). Carbamazepine level was positively correlated to triglycerides (r = 0.748, p = 0.013) and Valproate level was positively correlated to hs-CRP serum level (r = 0.556, p = 0.032).CONCLUSION:
Epilepsy and AED's are potential risk factors for atherosclerosis. Weak relation between epilepsy and/or AED's and lipid profile was found. Hs-CRP may be implicated in atherosclerosis in epileptic patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Epilepsia
/
Aterosclerosis
/
Anticonvulsivantes
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Int J Neurosci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Egipto