Motor and memory testing of long-lived pregnancy-associated plasma protein--a knock-out mice.
Growth Horm IGF Res
; 24(6): 251-5, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25179152
ABSTRACT
UNLABELLED Mice deficient in pregnancy-associated plasma protein-A (PAPP-A), an IGF binding protein protease, have been shown to be resistant to experimentally induced atherosclerosis and diabetic nephropathy, and, in the laboratory environment, live 30-40% longer than wild-type littermates in association with delayed incidence and occurrence of age-related neoplasms and degenerative diseases. OBJECTIVE:
PAPP-A is highly expressed in the cerebellum and hippocampus of the mouse brain. Therefore, the studies presented here were aimed at determining motor behavior, learning and retention in PAPP-A knock-out (KO) mice compared to wild-type (WT) littermates with age.DESIGN:
Balance and coordination were assessed using an accelerating rotarod; learning and memory were assessed in a Stone T-maze.RESULTS:
Time on the rotarod decreased with age but there was no significant difference between PAPP-A KO and WT mice at any of the testing ages. Latency to reach the goal box and number of errors committed in the Stone T-maze did not change with age and there were no significant differences between PAPP-A KO and WT mice.CONCLUSION:
Lack of PAPP-A in mice did not impact central regulation of coordination, learning or memory.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteína Plasmática A Asociada al Embarazo
/
Aprendizaje por Laberinto
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Prueba de Desempeño de Rotación con Aceleración Constante
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Longevidad
/
Memoria
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Neuronas Motoras
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Growth Horm IGF Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2014
Tipo del documento:
Article