Experimental detection of long-distance interactions between biomolecules through their diffusion behavior: numerical study.
Phys Rev E Stat Nonlin Soft Matter Phys
; 90(2): 022703, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-25215754
ABSTRACT
The dynamical properties and diffusive behavior of a collection of mutually interacting particles are numerically investigated for two types of long-range interparticle interactions Coulomb-electrostatic and dipole-electrodynamic. It is shown that when the particles are uniformly distributed throughout the accessible space, the self-diffusion coefficient is always lowered by the considered interparticle interactions, irrespective of their attractive or repulsive character. This fact is also confirmed by a simple model to compute the correction to the Brownian diffusion coefficient due to the interactions among the particles. These interactions are also responsible for the onset of dynamical chaos and an associated chaotic diffusion which still follows an Einstein-Fick-like law for the mean-square displacement as a function of time. Transitional phenomena are observed for Coulomb-electrostatic (repulsive) and dipole-electrodynamic (attractive) interactions considered both separately and in competition. The outcomes reported in this paper clearly indicate a feasible experimental method to probe the activation of resonant electrodynamic interactions among biomolecules.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Simulación por Computador
/
Modelos Moleculares
/
Modelos Biológicos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Phys Rev E Stat Nonlin Soft Matter Phys
Asunto de la revista:
BIOFISICA
/
FISIOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia