The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model.
Gravit Space Res
; 1(1): 79-94, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-25356435
ABSTRACT
Exposure to total-body radiation induces hematological changes, which can detriment one's immune response to wounds and infection. Here, the decreases in blood cell counts after acute radiation doses of γ-ray or proton radiation exposure, at the doses and dose-rates expected during a solar particle event (SPE), are reported in the ferret model system. Following the exposure to γ-ray or proton radiation, the ferret peripheral total white blood cell (WBC) and lymphocyte counts decreased whereas neutrophil count increased within 3 hours. At 48 hours after irradiation, the WBC, neutrophil, and lymphocyte counts decreased in a dose-dependent manner but were not significantly affected by the radiation type (γ-rays verses protons) or dose rate (0.5 Gy/minute verses 0.5 Gy/hour). The loss of these blood cells could accompany and contribute to the physiological symptoms of the acute radiation syndrome (ARS).
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MEDLINE
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Revista:
Gravit Space Res
Año:
2013
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Article
País de afiliación:
Panamá