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Grading and interpretation of white matter hyperintensities using statistical maps.
Ryu, Wi-Sun; Woo, Sung-Ho; Schellingerhout, Dawid; Chung, Moo K; Kim, Chi Kyung; Jang, Min Uk; Park, Kyoung-Jong; Hong, Keun-Sik; Jeong, Sang-Wuk; Na, Jeong-Yong; Cho, Ki-Hyun; Kim, Joon-Tae; Kim, Beom Joon; Han, Moon-Ku; Lee, Jun; Cha, Jae-Kwan; Kim, Dae-Hyun; Lee, Soo Joo; Ko, Youngchai; Cho, Yong-Jin; Lee, Byung-Chul; Yu, Kyung-Ho; Oh, Mi-Sun; Park, Jong-Moo; Kang, Kyusik; Lee, Kyung Bok; Park, Tai Hwan; Lee, Juneyoung; Choi, Heung-Kook; Lee, Kiwon; Bae, Hee-Joon; Kim, Dong-Eog.
Afiliación
  • Ryu WS; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Woo SH; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Schellingerhout D; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Chung MK; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kim CK; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Jang MU; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Park KJ; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Hong KS; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Jeong SW; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Na JY; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Cho KH; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kim JT; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kim BJ; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Han MK; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee J; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Cha JK; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kim DH; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee SJ; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Ko Y; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Cho YJ; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee BC; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Yu KH; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Oh MS; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Park JM; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kang K; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee KB; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Park TH; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee J; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Choi HK; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Lee K; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Bae HJ; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
  • Kim DE; From the Stroke Center and Korean Brain MRI Data Center, Dongguk University Ilsan Hospital, Goyang, Korea (W.-S.R., S.-H.W., S.-W.J., J.-Y.N., D.-E.K.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston (D.S.); Department of Biostatistics and Medical Informatics, Uni
Stroke ; 45(12): 3567-75, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25388424
ABSTRACT
BACKGROUND AND

PURPOSE:

We aimed to generate rigorous graphical and statistical reference data based on volumetric measurements for assessing the relative severity of white matter hyperintensities (WMHs) in patients with stroke.

METHODS:

We prospectively mapped WMHs from 2699 patients with first-ever ischemic stroke (mean age=66.8±13.0 years) enrolled consecutively from 11 nationwide stroke centers, from patient (fluid-attenuated-inversion-recovery) MRIs onto a standard brain template set. Using multivariable analyses, we assessed the impact of major (age/hypertension) and minor risk factors on WMH variability.

RESULTS:

We have produced a large reference data library showing the location and quantity of WMHs as topographical frequency-volume maps. This easy-to-use graphical reference data set allows the quantitative estimation of the severity of WMH as a percentile rank score. For all patients (median age=69 years), multivariable analysis showed that age, hypertension, atrial fibrillation, and left ventricular hypertrophy were independently associated with increasing WMH (0-9.4%, median=0.6%, of the measured brain volume). For younger (≤69) hypertensives (n=819), age and left ventricular hypertrophy were positively associated with WMH. For older (≥70) hypertensives (n=944), age and cholesterol had positive relationships with WMH, whereas diabetes mellitus, hyperlipidemia, and atrial fibrillation had negative relationships with WMH. For younger nonhypertensives (n=578), age and diabetes mellitus were positively related to WMH. For older nonhypertensives (n=328), only age was positively associated with WMH.

CONCLUSIONS:

We have generated a novel graphical WMH grading (Kim statistical WMH scoring) system, correlated to risk factors and adjusted for age/hypertension. Further studies are required to confirm whether the combined data set allows grading of WMH burden in individual patients and a tailored patient-specific interpretation in ischemic stroke-related clinical practice.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Sustancia Blanca Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Sustancia Blanca Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Año: 2014 Tipo del documento: Article