Production of rohitukine in leaves and seeds of Dysoxylum binectariferum: an alternate renewable resource.
Pharm Biol
; 53(3): 446-50, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25472605
ABSTRACT
CONTEXT Rohitukine is an important precursor for the synthesis of potential anticancer drugs flavopiridol (Sanofi-Aventis) and P-276-00 (Piramal Healthcare Limited, Mumbai, India). Trunk bark of Dysoxylum binectariferum (Roxb.) Hook. f. ex Bedd. (Meliaceae) is the widely used source for isolation of rohitukine. However, removal of trunk bark threatens the survival of the tree. OBJECTIVE:
To investigate the amount of rohitukine accumulated in other tissues of D. binectariferum. MATERIALS ANDMETHODS:
Rohitukine standard was isolated from leaves of D. binectariferum. Its purity was ascertained using HR-MS and NMR. Crude extracts were prepared from different tissues of D. binectariferum. Rohitukine content in all the tissues was quantified by HPLC.RESULTS:
Rohitukine accumulates in a significant amount in seeds, trunk bark, leaves, twigs, and fruits of D. binectariferum. Seeds have the highest rohitukine content (2.42%, dry weight) followed by trunk bark (1.34%, dry weight), leaves (1.064%, dry weight), twigs (0.844% dry weight), and fruits (0.4559% dry weight). DISCUSSION ANDCONCLUSION:
Seeds and leaves of D. binectariferum could be used as alternate renewable sources for isolation of rohitukine.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
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Semillas
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Extractos Vegetales
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Cromonas
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Hojas de la Planta
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Meliaceae
Idioma:
En
Revista:
Pharm Biol
Año:
2015
Tipo del documento:
Article