[Local immunotherapy of breast cancer: a case of advanced breast cancer improved by combined local injection therapy with OK-432 and rIL-2].
Gan To Kagaku Ryoho
; 16(8 Pt 2): 2760-3, 1989 Aug.
Article
en Ja
| MEDLINE
| ID: mdl-2551219
ABSTRACT
An effective immunotherapy for breast cancer has yet to be established. We have recently experienced an inoperable case of advanced breast cancer due to mental disorder. Combined local injection therapy with OK-432 and rIL-2 was performed in addition to non-surgical multi-disciplinary treatment, with obvious therapeutic effects. The case is a 67-year-old female, who had a 5.0 x 4.7 cm tumor in the area A of the left mammary gland. Aspiration cytologic examination revealed class V breast cancer. Besides systemic chemotherapy, local injection therapy with OK-432 2.0 KE on day 1 and rIL-2 500 U on day 3 was performed. Upon starting local injection therapy, a rapid reduction was noted in the tumor diameter (reduction rate, 75.5%). Tumor makers of CEA, CA 15-3 also showed obvious diminution. Although the dose and interval of administration remain to be further examined, the combined local injection therapy with OK-432 and rIL-2 was suggested to be an effective local immunotherapy for breast cancer.
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Banco de datos:
MEDLINE
Asunto principal:
Picibanil
/
Productos Biológicos
/
Neoplasias de la Mama
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Interleucina-2
/
Adenocarcinoma Escirroso
Límite:
Aged
/
Female
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Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
1989
Tipo del documento:
Article