Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A.

Ravi, Archna; Kaushik, Shelly; Ravichandran, Aarthi; Pan, Catherine Qiurong; Low, Boon Chuan

Ravi, Archna; Kaushik, Shelly; Ravichandran, Aarthi; Pan, Catherine Qiurong; Low, Boon Chuan.

Afiliación

Ravi A; From the Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore and the Mechanobiology Institute, National University of Singapore, 5A Engineering Drive, 117411 Singapore.
Kaushik S; From the Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore and the Mechanobiology Institute, National University of Singapore, 5A Engineering Drive, 117411 Singapore.
Ravichandran A; the Mechanobiology Institute, National University of Singapore, 5A Engineering Drive, 117411 Singapore.
Pan CQ; the Mechanobiology Institute, National University of Singapore, 5A Engineering Drive, 117411 Singapore.
Low BC; From the Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore and the Mechanobiology Institute, National University of Singapore, 5A Engineering Drive, 117411 Singapore dbslowbc@nus.edu.sg.

J Biol Chem ; 290(7): 4149-62, 2015 Feb 13.

Article en En | MEDLINE | ID: mdl-25525271

Asunto(s)

Factor de Crecimiento Epidérmico/farmacología; Quinasa 1 de Adhesión Focal/metabolismo; Adhesiones Focales/efectos de los fármacos; Proteínas Activadoras de GTPasa/metabolismo; Proteína Fosfatasa 2/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Western Blotting; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Células HEK293; Células HeLa; Humanos; Inmunoprecipitación; MAP Quinasa Quinasa 1/metabolismo; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Proteína Quinasa 3 Activada por Mitógenos/metabolismo; Fosforilación; Proteoma/análisis; Transducción de Señal; Cicatrización de Heridas

Palabras clave

Deleted In Liver Cancer 1 (DLC1); Focal Adhesion Kinase (FAK); GTPase-activating Protein (GAP); MEK/ERK; PTK2 Protein-tyrosine Kinase 2 (PTK2); Phosphorylation; Protein Phosphatase 2 (PP2A)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Activadoras de GTPasa / Adhesiones Focales / Proteínas Supresoras de Tumor / Factor de Crecimiento Epidérmico / Quinasa 1 de Adhesión Focal / Proteína Fosfatasa 2 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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