Aaptamine derivatives with antifungal and anti-HIV-1 activities from the South China Sea sponge Aaptos aaptos.
Mar Drugs
; 12(12): 6003-13, 2014 Dec 16.
Article
en En
| MEDLINE
| ID: mdl-25532563
ABSTRACT
Five new alkaloids of aaptamine family, compounds (1-5) and three known derivatives (6-8), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated by spectroscopic analyses, as well as by comparison with the literature data. Compounds 1-2 are characterized with triazapyrene lactam skeleton, whereas compounds 4-5 share an imidazole-fused aaptamine moiety. These compounds were evaluated in antifungal and anti-HIV-1 assays. Compounds 3, 7, and 8 showed antifungal activity against six fungi, with MIC values in the range of 4 to 64 µg/mL. Compounds 7-8 exhibited anti-HIV-1 activity, with inhibitory rates of 88.0% and 72.3%, respectively, at a concentration of 10 µM.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Poríferos
/
Fármacos Anti-VIH
/
Antifúngicos
/
Naftiridinas
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China