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Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.
Raitano, Susanna; Ordovàs, Laura; De Muynck, Louis; Guo, Wenting; Espuny-Camacho, Ira; Geraerts, Martine; Khurana, Satish; Vanuytsel, Kim; Tóth, Balazs I; Voets, Thomas; Vandenberghe, Rik; Cathomen, Toni; Van Den Bosch, Ludo; Vanderhaeghen, Pierre; Van Damme, Philip; Verfaillie, Catherine M.
Afiliación
  • Raitano S; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Ordovàs L; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • De Muynck L; Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; Research Group Experimental Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium.
  • Guo W; Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; Research Group Experimental Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium.
  • Espuny-Camacho I; Institute for Interdisciplinary Research (IRIBHM), Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium; Institute of Neuroscience (UNI), ULB, 1070 Brussels, Belgium; VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Geraerts M; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Khurana S; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Vanuytsel K; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Tóth BI; Laboratory of Ion Channel Research, KU Leuven, 3000 Leuven, Belgium.
  • Voets T; Laboratory of Ion Channel Research, KU Leuven, 3000 Leuven, Belgium.
  • Vandenberghe R; Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; Research Group Experimental Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium; Department of Neurology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Cathomen T; Institute for Cell and Gene Therapy, University Medical Center, 79108 Freiburg, Germany; Center for Chronic Immunodeficiency, University Medical Center, 79108 Freiburg, Germany.
  • Van Den Bosch L; Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; Research Group Experimental Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium.
  • Vanderhaeghen P; Institute for Interdisciplinary Research (IRIBHM), Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium; Institute of Neuroscience (UNI), ULB, 1070 Brussels, Belgium; VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center of Human Genetics, KU Leuven, 3000 Leuven, Belgium; Walloo
  • Van Damme P; Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; Research Group Experimental Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium; Department of Neurology
  • Verfaillie CM; Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium; Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium. Electronic address: catherine.verfaillie@med.kuleuven.be.
Stem Cell Reports ; 4(1): 16-24, 2015 Jan 13.
Article en En | MEDLINE | ID: mdl-25556567
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Expresión Génica / Péptidos y Proteínas de Señalización Intercelular / Neurogénesis / Células Madre Pluripotentes Inducidas / Demencia Frontotemporal / Neuronas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Stem Cell Reports Año: 2015 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Expresión Génica / Péptidos y Proteínas de Señalización Intercelular / Neurogénesis / Células Madre Pluripotentes Inducidas / Demencia Frontotemporal / Neuronas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Stem Cell Reports Año: 2015 Tipo del documento: Article País de afiliación: Bélgica