Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems.
Nanoscale
; 7(9): 3808-16, 2015 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-25566989
ABSTRACT
Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules. This kind of hybrid nanocomposite aims to combine the advantages of stimuli-responsive dendritic coatings, in order to regulate the drug release behaviour under different conditions and improve the biocompatibility and in vivo half-time circulation of the inorganic nanoparticles. Size, surface chemistry and shape are key nanocarrier properties to evaluate. Here, we have reviewed the most recent advances of NCDs in drug delivery systems, compared their behaviour with non-dendritic stabilized nanoparticles and highlighted their challenges and promising applications in the future.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Dendrímeros
/
Nanopartículas
Límite:
Humans
Idioma:
En
Revista:
Nanoscale
Año:
2015
Tipo del documento:
Article
País de afiliación:
Argentina