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The cryptophycins as potent payloads for antibody drug conjugates.
Verma, Vishal A; Pillow, Thomas H; DePalatis, Laura; Li, Guangmin; Phillips, Gail Lewis; Polson, Andrew G; Raab, Helga E; Spencer, Susan; Zheng, Bing.
Afiliación
  • Verma VA; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: verma.vishal@gene.com.
  • Pillow TH; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • DePalatis L; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Li G; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Phillips GL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Polson AG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Raab HE; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Spencer S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Zheng B; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Bioorg Med Chem Lett ; 25(4): 864-8, 2015 Feb 15.
Article en En | MEDLINE | ID: mdl-25613677
ABSTRACT
The cryptophycins are a potent class of cytotoxic agents that were evaluated as antibody drug conjugate (ADC) payloads. Free cryptophycin analog 1 displayed cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1. This potency increase was also reflected in the activity of the cryptophycin ADCs, attached via a either cleavable or non-cleavable linker.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoconjugados / Depsipéptidos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoconjugados / Depsipéptidos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article