Your browser doesn't support javascript.
loading
Elevated dairy fat intake in lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or synthesis.
Yahvah, Katherine M; Brooker, Sarah L; Williams, Janet E; Settles, Matthew; McGuire, Mark A; McGuire, Michelle K.
Afiliación
  • Yahvah KM; Department of Animal and Veterinary Science, University of Idaho, Moscow, ID, USA; Institute for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID, USA.
  • Brooker SL; Department of Animal and Veterinary Science, University of Idaho, Moscow, ID, USA; Institute for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID, USA.
  • Williams JE; Department of Animal and Veterinary Science, University of Idaho, Moscow, ID, USA; Institute for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID, USA; School of Biological Sciences, Washington State University, Pullman, WA, USA.
  • Settles M; Institute for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID, USA.
  • McGuire MA; Department of Animal and Veterinary Science, University of Idaho, Moscow, ID, USA; Institute for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID, USA.
  • McGuire MK; School of Biological Sciences, Washington State University, Pullman, WA, USA. Electronic address: smcguire@wsu.edu.
Nutr Res ; 35(3): 221-8, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25661476
ABSTRACT
Previous work has demonstrated that elevated maternal lipid intake (particularly from dairy products) is associated with increased lipids and altered fatty acid profile in milk produced by healthy lactating women. To investigate our primary hypothesis that a maternal diet rich in full-fat dairy products would simultaneously increase milk lipid percent and expression of genes related to the uptake and/or de novo biosynthesis of milk lipids, we provided 15 lactating women with diets enriched in full-fat or nonfat dairy products for 14 days each in a randomized, crossover study with a 2-week washout period. Milk fat (%) was lower when women consumed the low-fat compared with the full-fat dairy diet (2.41% ± 0.31% vs 3.35% ± 0.28%, respectively; P < .05); concentrations of more than 20 fatty acids also differed. However, neither conservatively evaluated microarray data nor quantitative real-time polymerase chain reaction analysis uncovered any treatment effects on expression of genes related to lipid synthesis or uptake. These data suggest that alteration in gene expression in the lactating human mammary gland is likely not the primary mechanism by which consumption of a high-fat diet affects milk fat percent in healthy, lactating women.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lactancia / Grasas de la Dieta / Expresión Génica / Lipogénesis / Ácidos Grasos / Dieta Alta en Grasa / Leche Humana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans Idioma: En Revista: Nutr Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lactancia / Grasas de la Dieta / Expresión Génica / Lipogénesis / Ácidos Grasos / Dieta Alta en Grasa / Leche Humana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans Idioma: En Revista: Nutr Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos