Controlled delivery of hollow corn protein nanoparticles via non-toxic crosslinking: in vivo and drug loading study.
Biomed Microdevices
; 17(1): 8, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25666984
ABSTRACT
In this research, controlled delivery of hollow nanoparticles from zein, the corn storage protein, to different organs of mice was achieved via crosslinking using citric acid, a non-toxic polycarboxylic acid derived from starch. Besides, crosslinking significantly enhanced water stability of nanoparticles while preserving their drug loading efficiency. Protein nanoparticles have been widely investigated as vehicles for delivery of therapeutics. However, protein nanoparticles were not stable in physiological conditions, easily cleared by mononuclear phagocyte system (MPS), and thus mainly accumulated and degraded in spleen and liver, the major MPS organs. Effective delivery to major non-MPS organs, such as kidney, was usually difficult to achieve, as well as long resident time of nanoparticles. In this research, hollow zein nanoparticles were chemically crosslinked with citric acid. Controlled delivery and prolonged accumulation of the nanoparticles in kidney, one major non-MPS organ, were achieved. The nanoparticles showed improved stability in aqueous environment at pH 7.4 without affecting the adsorption of 5-FU, a common anticancer drug. In summary, citric acid crosslinked hollow zein nanoparticles could be potential vehicles for controllable delivery of anticancer therapeutics.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ácido Cítrico
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Zea mays
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Reactivos de Enlaces Cruzados
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Nanopartículas
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Proteínas de Almacenamiento de Semillas
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Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Biomed Microdevices
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos