Inhibition screening method of microsomal UGTs using the cocktail approach.

Gradinaru, Julieta; Romand, Stéphanie; Geiser, Laurent; Carrupt, Pierre-Alain; Spaggiari, Dany; Rudaz, Serge

Gradinaru, Julieta; Romand, Stéphanie; Geiser, Laurent; Carrupt, Pierre-Alain; Spaggiari, Dany; Rudaz, Serge.

Afiliación

Gradinaru J; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Romand S; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Geiser L; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Carrupt PA; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Spaggiari D; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Rudaz S; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland. Electronic address: serge.rudaz@unige.ch.

Eur J Pharm Sci ; 71: 35-45, 2015 Apr 25.

Article en En | MEDLINE | ID: mdl-25684194

Asunto(s)

Glucuronosiltransferasa/antagonistas & inhibidores; Microsomas Hepáticos/metabolismo; Inhibidores Enzimáticos/farmacología; Glucurónidos/metabolismo; Glucuronosiltransferasa/metabolismo; Humanos

Palabras clave

Azidothymidine (PubChem CID: 35370); Chenodeoxycholic acid (PubChem CID: 10133); Cocktail approach; Codeine (PubChem CID: 5284371); Etoposide (PubChem CID: 3310); Human liver microsomes; Isoferulic acid (PubChem CID: 736186); Levomedetomidine (PubChem CID: 60612); Phase II metabolism; Serotonin (PubChem CID: 5202); Testosterone (PubChem CID: 6013); Trifluoperazine (PubChem CID: 5566); UGT inhibition; UHPLCTOF; d,l-4-Hydroxy-3-methoxymethamphetamine (PubChem CID: 3081137)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microsomas Hepáticos / Glucuronosiltransferasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Suiza

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