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Manganese superoxide dismutase (MnSOD Val-9Ala) gene polymorphism and susceptibility to gastric cancer.
Moradi, Mohammad-Taher; Yari, Kheirollah; Rahimi, Zohreh; Kazemi, Elham; Shahbazi, Mehrdad.
Afiliación
  • Moradi MT; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran E-mail : kyari@kums.ac.ir.
Asian Pac J Cancer Prev ; 16(2): 485-8, 2015.
Article en En | MEDLINE | ID: mdl-25684475
BACKGROUND: Oxidative stress caused by the generation of reactive oxygen species plays an important role in human carcinogenesis. Manganese superoxide dismutase (MnSOD) Val-9Ala in the mitochondrial target sequence is the best known polymorphism of this enzyme. The purpose of the current research was to assess the association of MnSOD Val-9Ala genotypes with the risk of gastric cancer. MATERIALS AND METHODS: This case- control study covered 54 gastric cancer patients compared to 100 cancer free subjects as controls. Extraction of DNA was performed on bioptic samples and genotypes were identified with a polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: The frequencies of MnSOD Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 24.3, 66.7 and 9%, respectively. However, in gastric cancer patients, Ala/Ala, Ala/Val and Val/Val were observed in 24.0, 48.0 and 28.0% (p=0.01). In patients the frequency of MnSOD Val allele was higher (52%) compared to that in controls (42%). CONCLUSIONS: The results of this study show a positive association between MnSOD Val-9Ala gene polymorphism and risk of gastric cancer disease in Iranian population.
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Banco de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Gástricas / Superóxido Dismutasa / Biomarcadores de Tumor / Mucosa Gástrica Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Gástricas / Superóxido Dismutasa / Biomarcadores de Tumor / Mucosa Gástrica Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article