The role of STAT3 in tumor-mediated immune suppression.

Ferguson, Sherise D; Srinivasan, Visish M; Heimberger, Amy B

Ferguson, Sherise D; Srinivasan, Visish M; Heimberger, Amy B.

Afiliación

Ferguson SD; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Blvd., Unit 442, Houston, TX, 77030, USA, sdferguson@mdanderson.org.

J Neurooncol ; 123(3): 385-94, 2015 Jul.

Article en En | MEDLINE | ID: mdl-25700834

ABSTRACT

ABSTRACT

The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

Asunto(s)

Neoplasias Encefálicas; Glioblastoma; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/inmunología; Animales; Neoplasias Encefálicas/inmunología; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/terapia; Glioblastoma/inmunología; Glioblastoma/metabolismo; Glioblastoma/terapia; Humanos; Inmunosupresores/metabolismo; Inmunosupresores/uso terapéutico; Factor de Transcripción STAT3/deficiencia; Transducción de Señal/efectos de los fármacos

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Transducción de Señal / Glioblastoma / Factor de Transcripción STAT3 Límite: Animals / Humans Idioma: En Revista: J Neurooncol Año: 2015 Tipo del documento: Article

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