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Parkinson's disease iron deposition caused by nitric oxide-induced loss of ß-amyloid precursor protein.
Ayton, Scott; Lei, Peng; Hare, Dominic J; Duce, James A; George, Jessica L; Adlard, Paul A; McLean, Catriona; Rogers, Jack T; Cherny, Robert A; Finkelstein, David I; Bush, Ashley I.
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  • Ayton S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Lei P; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Hare DJ; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia, Elemental Bio-imaging Facility, University of Technology Sydney, Broadway, New South Wales, 2007, Australia, and Department of Preventive Medicine, Icahn School of Medicine at Mount Sina
  • Duce JA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, North Yorkshire, LS2 9JT, United Kingdom.
  • George JL; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Adlard PA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • McLean C; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia, Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria 3004, Australia.
  • Rogers JT; Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital (East), Charlestown, Massachusetts 02129.
  • Cherny RA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Finkelstein DI; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
  • Bush AI; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia, ashley.bush@florey.edu.au.
J Neurosci ; 35(8): 3591-7, 2015 Feb 25.
Article en En | MEDLINE | ID: mdl-25716857
Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer-associated ß-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that APP(-/-) mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Precursor de Proteína beta-Amiloide / Hierro / Óxido Nítrico Límite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2015 Tipo del documento: Article País de afiliación: Australia
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Precursor de Proteína beta-Amiloide / Hierro / Óxido Nítrico Límite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2015 Tipo del documento: Article País de afiliación: Australia