Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase.

Srividya, Narayanan; Davis, Edward M; Croteau, Rodney B; Lange, B Markus

Srividya, Narayanan; Davis, Edward M; Croteau, Rodney B; Lange, B Markus.

Afiliación

Srividya N; Institute of Biological Chemistry and M. J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA 99163.
Davis EM; Institute of Biological Chemistry and M. J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA 99163.
Croteau RB; Institute of Biological Chemistry and M. J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA 99163 croteau@wsu.edu lange-m@wsu.edu.
Lange BM; Institute of Biological Chemistry and M. J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA 99163 croteau@wsu.edu lange-m@wsu.edu.

Proc Natl Acad Sci U S A ; 112(11): 3332-7, 2015 Mar 17.

Article en En | MEDLINE | ID: mdl-25733883

Asunto(s)

Biocatálisis; Liasas Intramoleculares/genética; Modelos Biológicos; Mutación/genética; Alanina/genética; Mentha spicata/enzimología; Modelos Moleculares; Mutagénesis/genética; Proteínas Mutantes/metabolismo; Especificidad por Sustrato; Terpenos/química; Terpenos/metabolismo

Palabras clave

carbocation; enzyme catalysis; mechanism; monoterpene synthase; structurefunction relationship

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Liasas Intramoleculares / Biocatálisis / Modelos Biológicos / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article

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