[Experimental studies on combination chemotherapy of cisplatin with peplomycin against human squamous cell carcinomas in nude mice].
Gan To Kagaku Ryoho
; 12(1): 70-6, 1985 Jan.
Article
en Ja
| MEDLINE
| ID: mdl-2578275
ABSTRACT
Combination chemotherapy of cisplatin (CDDP) with bleomycin (BLM) or peplomycin (PEP) has exhibited clinical efficacy against squamous cell carcinomas. The combination of CDDP with PEP was studied using five human squamous cell carcinomas in nude mice. When CDDP was administered before PEP treatment, the combination effect was more pronounced than when CDDP was administered after PEP treatment. Especially, when CDDP was administered 5 or 3 days before PEP treatment, marked delay in growth was shown in 4 out of the 5 human carcinomas. From these results, it is thought that human heterotransplanted tumors in nude mice may provide important information in studies of combination chemotherapy.
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Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Protocolos de Quimioterapia Combinada Antineoplásica
Límite:
Animals
/
Humans
/
Male
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
1985
Tipo del documento:
Article