Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice.

Liu, Zhi-Qin; Liu, Ting; Chen, Chuan; Li, Ming-Yan; Wang, Zi-Yu; Chen, Ruo-Song; Wei, Gui-Xiang; Wang, Xiao-Yi; Luo, Du-Qiang

Liu, Zhi-Qin; Liu, Ting; Chen, Chuan; Li, Ming-Yan; Wang, Zi-Yu; Chen, Ruo-Song; Wei, Gui-Xiang; Wang, Xiao-Yi; Luo, Du-Qiang.

Afiliación

Liu ZQ; College of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR C
Liu T; College of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
Chen C; College of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
Li MY; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR China.
Wang ZY; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR China.
Chen RS; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR China.
Wei GX; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR China.
Wang XY; College of Pharmaceutical Sciences, key laboratory of pharmaceutical quality control of Hebei province, Hebei University, Baoding 071002, PR China.
Luo DQ; College of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China. Electronic address: duqiangluo999@126.com.

Toxicol Appl Pharmacol ; 285(1): 61-70, 2015 May 15.

Article en En | MEDLINE | ID: mdl-25796170

Asunto(s)

Diabetes Mellitus/tratamiento farmacológico; Inhibidores Enzimáticos/farmacología; Ácidos Hidroxámicos/farmacología; Hipoglucemiantes/farmacología; Resistencia a la Insulina; Insulina/metabolismo; Hígado/efectos de los fármacos; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Piridonas/farmacología; Transducción de Señal/efectos de los fármacos; Animales; Biomarcadores/sangre; Glucemia/efectos de los fármacos; Glucemia/metabolismo; Diabetes Mellitus/sangre; Diabetes Mellitus/enzimología; Modelos Animales de Enfermedad; Relación Dosis-Respuesta a Droga; Células Hep G2; Humanos; Hígado/enzimología; Masculino; Ratones; Ratones Endogámicos C57BL; Fosforilación; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Factores de Tiempo

Palabras clave

Diabetes mellitus; Glucose uptake; Insulin resistance; Insulin signaling; Protein tyrosine phosphatase 1B

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Resistencia a la Insulina / Transducción de Señal / Diabetes Mellitus / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Ácidos Hidroxámicos / Hipoglucemiantes / Insulina / Hígado Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Año: 2015 Tipo del documento: Article

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