Metabolism of 3-methylcholanthrene in rat liver cytosol.
Chem Biol Interact
; 71(4): 393-401, 1989.
Article
en En
| MEDLINE
| ID: mdl-2582542
ABSTRACT
The present study investigates the metabolism of the potent carcinogen 3-methylcholanthrene in rat liver cytosol preparations. Three metabolites of 3-methylcholanthrene were characterized by HPLC and GC/MS analysis. These metabolites were identified as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene and cholanthrene. The results of the present study, taken together with earlier studies, suggests that the first step in the metabolic activation of 3-methylcholanthrene is hydroxylation at the 1-position, the most easily oxidized reactive center in the molecule.
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Banco de datos:
MEDLINE
Asunto principal:
Hígado
/
Metilcolantreno
Límite:
Animals
Idioma:
En
Revista:
Chem Biol Interact
Año:
1989
Tipo del documento:
Article