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Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, Sandra; Bruning, Ulrike; Missiaen, Rindert; Queiroz, Karla Cs; Borgers, Gitte; Elia, Ilaria; Zecchin, Annalisa; Cantelmo, Anna Rita; Christen, Stefan; Goveia, Jermaine; Heggermont, Ward; Goddé, Lucica; Vinckier, Stefan; Van Veldhoven, Paul P; Eelen, Guy; Schoonjans, Luc; Gerhardt, Holger; Dewerchin, Mieke; Baes, Myriam; De Bock, Katrien; Ghesquière, Bart; Lunt, Sophia Y; Fendt, Sarah-Maria; Carmeliet, Peter.
Afiliación
  • Schoors S; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Bruning U; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Missiaen R; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Queiroz KC; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Borgers G; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Elia I; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Zecchin A; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Cantelmo AR; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Christen S; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Goveia J; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Heggermont W; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Goddé L; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Vinckier S; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Van Veldhoven PP; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Eelen G; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Schoonjans L; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Gerhardt H; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Dewerchin M; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Baes M; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • De Bock K; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Ghesquière B; Center for Molecular & Vascular Biology, KU Leuven; Division of Clinical Cardiology, UZ Leuven, B-3000, Belgium.
  • Lunt SY; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
  • Fendt SM; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, B-3000, Belgium.
  • Carmeliet P; Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium.
Nature ; 520(7546): 192-197, 2015 Apr 09.
Article en En | MEDLINE | ID: mdl-25830893
Asunto(s)
Carbono/metabolismo; Células Endoteliales/metabolismo; Ácidos Grasos/química; Ácidos Grasos/metabolismo; Nucleótidos/biosíntesis; Ácido Acético/farmacología; Adenosina Trifosfato/metabolismo; Animales; Vasos Sanguíneos/citología; Vasos Sanguíneos/efectos de los fármacos; Vasos Sanguíneos/metabolismo; Vasos Sanguíneos/patología; Carnitina O-Palmitoiltransferasa/antagonistas & inhibidores; Carnitina O-Palmitoiltransferasa/deficiencia; Carnitina O-Palmitoiltransferasa/genética; Carnitina O-Palmitoiltransferasa/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Ciclo del Ácido Cítrico; ADN/biosíntesis; Modelos Animales de Enfermedad; Células Endoteliales/citología; Células Endoteliales/efectos de los fármacos; Células Endoteliales/enzimología; Silenciador del Gen; Glucosa/metabolismo; Células Endoteliales de la Vena Umbilical Humana/citología; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Células Endoteliales de la Vena Umbilical Humana/patología; Humanos; Ratones; Neovascularización Patológica/tratamiento farmacológico; Neovascularización Patológica/metabolismo; Neovascularización Patológica/patología; Nucleótidos/química; Nucleótidos/farmacología; Oxidación-Reducción/efectos de los fármacos; Retinopatía de la Prematuridad/tratamiento farmacológico; Retinopatía de la Prematuridad/metabolismo; Retinopatía de la Prematuridad/patología
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carbono / Células Endoteliales / Ácidos Grasos / Nucleótidos Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carbono / Células Endoteliales / Ácidos Grasos / Nucleótidos Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article País de afiliación: Bélgica